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News

Loss of SIRT1 in Memory T Cells During Aging

Melanie Ott

SANTA FE, NM--March 10, 2015--Graduate student Mark Jeng delivers an oral presentation of his project "Loss of SIRT1 promotes metabolic reprogramming in memory T cells during aging and chronic infections" at the annual Keystone Symposium: Biology of Sirtuins. He received a UCSF Graduate Division Travel award to sponsor his attendance at this conference.

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Using Viruses to Find the Cellular Achilles Heel

Melanie Ott

SAN FRANCISCO, CA—January 22, 2015­—A study from researchers at the Gladstone Institutes has exposed new battle tactics employed by the hepatitis C virus (HCV). Published in the January 22 issue of Molecular Cell, the investigators created full protein interaction maps—interactomes—of where the virus comes into contact with the host proteins during the course of infection. Through these protein interactions, the scientists not only gained insight into the virus, they also uncovered a common set of host proteins that are targeted by various infections. Their results suggest that these proteins and the cellular processes they govern are the most crucial—in effect, the collective Achilles heel—for both the human body and its viral invaders.

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Melanie Receives 2014 Avant-Garde Award for HIV/AIDS Research

Melanie Ott

Three scientists, including Gladstone's Melanie Ott, MD, PhD, have been chosen to receive the 2014 Avant-Garde Award for HIV/AIDS Research from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. The three scientists will each receive $500,000 per year for five years to support their research.

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Navigating the Road from DNA to RNA—and Beyond

Melanie Ott

In the latest issue of Molecular Cell, researchers in the laboratory of Gladstone Investigator Melanie Ott, MD, PhD, describe the intriguing behavior of a protein called RNA polymerase II (RNAPII). The RNAPII protein is an enzyme, a catalyst that guides the transcription process by copying DNA into RNA, which forms a disposable blueprint for making proteins. Scientists have long known that RNAPII appears to stall or “pause” at specific genes early in transcription. But they were not sure as why.

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Gladstone Scientists Link Hepatitis C Virus Infection to Fat Enzyme in Liver Cells

Melanie Ott

SAN FRANCISCO, CA—October 10, 2010—Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have found that an enzyme associated with the storage of fat in the liver is required for the infectious activity of the hepatitis C virus (HCV). This discovery may offer a new strategy for treating the infection.

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