Sarah recently presented her work at the 2019 FASEB meeting on Protein Acetylation in Disease in Lisbon, Portugal. She gave a phenomenal talk on her work titled, “Regulatory Role for NF-kB/RelA K310 Acetylation Identified In Vivo by a CRISPR Knock-in Approach”, and was a recipient of the “Best Poster” award.
Congrats to Sarah McMahon who was recently awarded the Tobacco-related Disease Research Program (TRDRP) fellowship to study the role of NF-kB acetylation in models of therapeutic resistance in non-small cell lung cancer.
Dr. Melanie Ott was nominated for and accepted an NIH Merit Award for her R01 “Role of Factor Acetylation in the Regulation of HIV transcription”. Merit awards enable NIH Institutes to give investigators with stellar records of research accomplishment a five-year award with the possibility of extending the initial award for up to five additional years without undergoing another IRG peer review.
Ott Lab graduate student Camille Simoneau spoke at the 9th Annual Bay Area Symposium on Viruses, on June 7, 2019. Camille’s talk was titled “Modeling CB8+ T cell responses against liver infection with 3D organoids”, and she was one of only two graduate students chosen to give a talk at the event.
Great job, Camille!
Ott Lab postdoctoral scholar Nathan Meyers gave a talk entitled “Hepatitis C virus infects and perturbs liver stem cells” at the UCSF Mini-Symposium on Liver Stem Cells on May 30, 2019. The Mini-Symposium was part of the UCSF Liver Center’s annual programming, and included talks from researchers at Gladstone, UCSF, and Stanford University.
Great job, Nathan!
This year at Gladstone’s Scientific Retreat, several members of the Ott Lab presented their research. Postdoctoral scholar Nathan Meyers gave a talk entitled “HCV Infects and Perturbs Liver Stem Cells”, which received great interest from Gladstone colleagues. Lab members Jennifer Hayashi, Camille Simoneau, Parinaz Fozouni, Albert Vallejo-Gracia, Kristoffer Leon, and Sarah McMahon presented posters, with Parinaz winning a ‘Best Poster’ award.
Congrats, Parinaz, and great job to everyone who presented!
Kristoffer Leon, a graduate student in the Ott Lab, has been awarded the Ruth L. Kirschstein National Research Service Award for his project ‘Understanding the Role of RNA Surveillance Mechanisms in Neuropathogenesis during Zika Virus Infection’. This is an F31 that will help Kris fund his education and research.
Former Ott Lab intern Musette Caldera has been accepted to San Francisco State's Masters Program in Cell and Molecular Biology. Musette was also awarded the NIH Bridges to PhD Fellowship. She will begin her studies this coming Fall 2019.
Kristoffer Leon received an impact score of 10 (top 1%) on his F31 application on his project ‘Understanding the Role of RNA Surveillance Mechanisms in Neuropathogenesis during Zika Virus Infection’. Awards will be announced later this year.
Dr. Ott was on the scientific organizing committee for the April 24-29, 2019 Keystone Symposia, Functional Cures and the Eradication of HIV. The meeting took place in Whistler, British Columbia, and was very well attended.
The Ott Lab, in collaboration with Drs Niren Murthy, and Nir Yusef at UC Berkeley as well as Dr. Steven Deeks at UCSF, was awarded an R61 grant by the National Institute of Health’s National Institute on Drug Abuse (NIDA). This grant will enable the Ott Lab to study primary latently infected T cells isolated from aviremic HIV-infected drug users using single-cell RNA-Seq and CRISPR technology.
In more good news, the Ott Lab’s recent R01 renewal ranked in the 3rd percentile during review at NIAID.
Ott Lab postdoctoral scholar Ibraheem Ali’s latest paper ‘Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins’ has been accepted for publication by Molecular Cell Journal. This will be Dr. Ali’s fourth first-author paper, and will be published later in the year.
The Ott Lab started off 2019 by adding two new postdoctoral scholars, Gili Aviv and Danielle Lyons. We are very excited to have these two join our team! Welcome, Gili and Danielle!
To learn more about our lab members, scroll over the ‘People’ button, and select ‘Lab Members’.
On December 21st, 2018, Ibs gave his exit talk, one of the final stages of completing his PhD. Ibs will continue to work in the Ott Lab as a postdoctoral scholar while he works on a manuscript for publication.
Congrats, Dr. Ali!
Krystal and Kris’ paper “The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein” has been accepted for publishing by mBio! Co-authors include Mir Khalid, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia A Kaye, Priya S Shah, Steve Finkbeiner, Nevan J. Krogan, and Melanie Ott.
Congrats, Krystal and Kris!
Dr. Melanie Ott was awarded a Chan Zuckerberg Intercampus Research Award for her project “Defining host responses of virus- infected and uninfected neighbor cells”. This funding from the CZ Biohub will foster further scientific research collaboration between Stanford, the University of California at Berkeley, and the University of California at San Francisco. More information about the award can be found here.
Congratulations, Dr. Ott!
Ott Lab MD/PhD student Kristoffer Leon passed his qualifying exam on September 21, making him an official PhD candidate! Congrats, Kris!
Ott Lab summer intern Juan Torres presented the research he did with postdoc Nathan Meyers on August 1st. Juan's presentation was entitled "Using Liver Stem Cells to Develop a 3D Model for Studying Hepatitis C". Juan will return to UCLA in the fall to complete his undergraduate studies.
Great job, Juan!
On June 22nd, Philip Ansumana Hull successfully defended his thesis and earned his PhD. His thesis work focused on immune aging, T cell biology, and T cell metabolism. This included identifying a novel evolutionary conserved SIRT1-FoxO1 axis that regulates CD8+ memory T cell metabolism and cytotoxicity. His last day in the Ott Lab was July 31st, and he is now off to work for Bristol-Meyers Squibb.
Congratulations, Ansu, and good luck at your new job!
Second year BMS student and Ott Lab graduate student Camille Simoneau passed her qualifying exam on July 26, making her an official PhD candidate! Congrats, Camille!