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All Publications

Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Mol Cell. 2017 Aug 17. pii: S1097-2765(17)30549-X. doi: 10.1016/j.molcel.2017.07.025.

Boehm D, Ott M. Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines. Bio Protoc. 2017 May 20;7(10). pii: e2290. doi: 10.21769/BioProtoc.2290.


Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Cell Host Microbe. 2017 May 10;21(5):569-579.e6.

2016

Ali I, Conrad R, Ott M (2016) Retrovirus integration: some assembly required?  Cell Host Microbe.

Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, STevensson JP, Gramatica A, Conrad R, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E (2016). Genome-wide shRNA Profiling Reveals a Novel Role for mTOR in HIV Latency.  Cell Host Microbe.

Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. (2016) Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allow enhanced viral replication. J Exp Med

Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F; International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. (2016) International AIDS Society global scientific strategy: towards an HIV cure 2016.  Nat Med.

Ali I, Ramage H, Boehm D, Dirk LMA, Sakane N, Hanada, K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. (2016) The HIV-1 Tat protein is monomethylated at lysine-71 by the lysine methyltransferase KMT7.  J Biol Chem.

Meyers N, Fontaine K, Ott M. (2016) Entangled in a membranous web: ER and lipid droplet reorganization during Hepatitis C virus infection. Curr Opin Cell Biol

Shirakawa K, Wang L, Man N, Maksimoska J,Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E (2016) Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife

Rosenkranz E, Metz CHD, Maywald M, Hilgers RD, Wessels I, Senff T, Haase H, Jaeger M, Ott M, Aspinall R, Pumaekers B, Rink L. (2016) Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Mol Nutr Food Res

Conrad RJ, Ott M (2016) Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses. ACS Chem Biol

2015

Jeng MY, Ali I, Ott M (2015) Manipulation of the host protein acetylation network by human immunodeficiency virus type 1. Crit Rev Biochem Mol Bio 50:314-325.

Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnolzer M, Kasler HG, Kwon H-S, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E (2015) SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med 212:973

Ramage HR, Kumar GR, Verschueren E, Johnson JR, Dollen Von J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M (2015) A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell 57:329–340.

Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA (2015) Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. BMC Evol Biol 15:35.

 

2014

Verdin E, Ott M (2014) 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat Rev Mol Cell Biol.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou C-L, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M (2014) The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem

 

2013

Webster B, Ott M, Greene WC (2013) Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol 87:13354–13369.

Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnolzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M (2013) Acetylation of RNA Polymerase II Regulates Growth-Factor-Induced Gene Transcription in Mammalian Cells. Mol Cell 52:314–324.

Verdin E, Ott M (2013) Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria. Mol Cell 51:132–134.

Ott M, Verdin E (2013) Three rules for HIV latency: location, location, and location. Cell Host Microbe 13:625–626.

Boehm D, Conrad R, Ott M (2013) Bromodomain Proteins in HIV Infection. Viruses 5:1571–1586. doi: 10.3390/v5061571

Camus G, Ott M (2013) How the antiviral immune response boosts liver fat. Nat Med 19:671–672.

Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M (2013) Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem 288:9915–9923.

Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li P-C, Planelles V, Bradner JE, Zhou M-M, Siliciano RF, Weinberger L, Verdin E, Ott M (2013) BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle 12:452–462.

Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM (2013) Snapshots: Chromatin control of viral infection. Virology 435:141–156.

Webster B, Wissing S, Herker E, Ott M, Greene WC (2013) Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol 87:581–596.

Vogt DA, Camus G, Herker E, Webster BR, Tsou C-L, Greene WC, Yen T-SB, Ott M (2013) Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. PLoS Pathog 9:e1003302.

Camus G, Vogt DA, Kondratowicz AS, Ott M (2013) Lipid droplets and viral infections. Methods Cell Biol 116:167–190.

 

2012

Kwon HS, Lim HW, Wu J, Schnolzer M, Verdin E, Ott M (2012) Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells. J Immunol 188:2712–2721.

Herker E, Ott M (2012) Emerging role of lipid droplets in host/pathogen interactions. J Biol Chem 287:2280–2287.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnolzer M, Verdin E, Zhou M-M, Ott M (2012) Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem 287:1090–1099.

 

2011

Harris C, Herker E, Farese RV, Ott M (2011) Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem 286:42615–42625.

Ott M, Geyer M, Zhou Q (2011) The Control of HIV Transcription: Keeping RNA Polymerase II on Track. Cell Host Microbe 10:426–435.

Sakane N, Kwon H-S, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M (2011) Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog 7:e1002184.

Herker E, Ott M (2011) Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab 22:241–248.

Pagans S, Sakane N, Schnolzer M, Ott M (2011) Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies. Methods 53:91–96.

Ott M (2011) HIV never ceases to surprise: Innovative methods in the quest for a cure. Methods 53:1–2.

 

2010

Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M (2010) Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med 16:1295–1298.

Min S-W, Cho S-H, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67:953–966.

Ott M, Verdin E (2010) HAT trick: p300, small molecule, inhibitor. Chem Biol 17:417–418.

Cho S, Schroeder S, Ott M (2010) CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation. Cell Cycle 9:1697–1705.

Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M (2010) The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe 7:234–244.

 

2009

Cho S, Schroeder S, Kaehlcke K, Kwon H-S, Pedal A, Herker E, Schnoelzer M, Ott M (2009) Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells. EMBO J 28:1407–1417.

 

2008

Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH (2008) Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci 28:12305–12317.

Kwon H-S, Ott M (2008) The ups and downs of SIRT1. Trends Biochem Sci 33:517–525.

Kwon H-S, Brent MM, Getachew R, Jayakumar P, Chen L-F, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M (2008) Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe 3:158–167.

 

2007

Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M (2007) Recruitment and activation of RSK2 by HIV-1 Tat. PLoS ONE 2:e151.

Nieters A, Kallinowski B, Brennan P, Ott M, Maynadié M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, De Sanjosé S (2006) Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH. Gastroenterology 131:1879–1886.

 

2006

Mahmoudi T, Parra M, Vries RGJ, Kauder SE, Verrijzer CP, Ott M, Verdin E (2006) The SWI/SNF Chromatin-remodeling Complex Is a Cofactor for Tat Transactivation of the HIV Promoter. J Biol Chem 281:19960–19968.

 

2005

Hetzer C, Dormeyer W, Schnolzer M, Ott M (2005) Decoding Tat: the biology of HIV Tat posttranslational modifications. Microbes Infect 7:1364–1369.

Dormeyer W, Ott M, Schnolzer M (2005) Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Mol Cell Proteomics 4:1226–1239.

Dormeyer W, Ott M, Schnolzer M (2005) Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry. Methods 36:376–382.

Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M (2005) SIRT1 Regulates HIV Transcription via Tat Deacetylation. Plos Biol 3:e41.

 

2004

Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TSB, Ott M (2004) Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 78:7958–7968.

Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS (2004) HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane. Mol Cell 13:179–190.

Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou M-M, Verdin E (2004) Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp 259:182–93– discussion 193–6– 223–5.

 

2003

Dormeyer W, Dorr A, Ott M, Schnolzer M (2003) Acetylation of the HIV-1 Tat protein: an in vitro study. Anal Bioanal Chem 376:994–1005.

Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M (2003) Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell 12:167–176.

 

2002

Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M (2002) Release and intercellular transfer of cell surface CD81 via microparticles. J Immunol 169:5531–5537.

Schwer B, North BJ, Frye RA, Ott M, Verdin E (2002) The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 158:647–657.

Dorr A, Kiermer V, Pedal A, Rackwitz H-R, Henklein P, Schubert U, Zhou M-M, Verdin E, Ott M (2002) Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J 21:2715–2723.

Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou M-M (2002) Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell 9:575–586.

 

1999

Ott M, Schnolzer M, Garnica J, Fischle W, Emiliani S (1999) Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity. Curr Biol 9:1489-92.

 

1998

Emiliani S, Fischle W, Ott M, Van Lint C, Amella CA, Verdin E (1998) Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line. J Virol 72:1666-70.

Ott M, Lovett JL, Mueller L, Verdin E (1998) Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-κB factors. J Immunol 160:2872-80.

 

1997

McCloskey TW, Ott M, Tribble E, Khan SA, Teichberg S, Paul MO, Pahwa S, Verdin E, Chirmule N (1997) Dual role of HIV Tat in regulation of apoptosis in T cells. J. Immunol 158:1014-9.

Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J (1997) Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science 275:1481-5.

 

1996

Emiliani S, Van Lint C, Fischle W, Paras P, Ott M, Brady J, Verdin E (1996) A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency. Proc Natl Acad Sci U S A 93:6377-81.